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PhD thesis: Engineering of Toxoplasma gondii restricted in their host-cell specificity

Einrichtung: Tierärztliche Fakultät
(Lehrstuhl für Experimentelle Parasitologie)
Besetzungsdatum: 01.06.2019
Ende der Bewerbungsfrist: 15.05.2019
Entgeltgruppe: E13
Befristung: drei Jahre

Es handelt sich um eine Teilzeitstelle. (Stundenzahl: 26)

Die Ludwig-Maximilians-Universität München (LMU) ist eine der renommiertesten und größten Universitäten Deutschlands.


We are looking for highly motivated PhD students with interest in cellular biology and parasitology who want to work on fundamental biological aspects of the apicomplexan parasite Toxoplasma gondii and its host cell.
Toxoplasma has the potential to invade all nucleated cells of warm-blooded animals, but how it accomplishes this impressive feat is unclear. The goal of this research project is to understand the molecular mechanisms involved in this process and to translate this knowledge into engineering of host-cell-type specific parasites. For relevant background look at the following publications (Kessler H et al., J Cell Sci. 2008; Manzoni G et al., Elife. 2017, Sidik SM et al., Cell. 2016; Andenmatten N, et al., Nat Methods. 2013). In the long term, we aim to assess if cell specific invasion of Toxoplasma can be utilized for intracellular antigen delivery in cross species immunisations. The project is funded by the research grant “Experiment!” of the VolkswagenStiftung.


Applicants are required to hold or to obtain a first-class or upper second class Master degree in veterinary medicine, biology, biochemistry, microbiology, or a related relevant subject. They should have excellent theoretical knowledge of molecular biology and good laboratory skills. Experience or a strong interest in molecular biology and/or imaging is favorable.
The lab of Markus Meissner is based in the Faculty of Veterinary Medicine. Numerous core facilities ensure state of the art equipment and expertise.

Wir bieten Ihnen eine interessante und verantwortungsvolle Tätigkeit mit guten Weiterbildungs- und Entwicklungsmöglichkeiten. Schwerbehinderte Bewerber / Bewerberinnen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt. Die Bewerbung von Frauen wird begrüßt.


Please send your complete application as a single PDF to:

Dr. Mirko Singer
Experimental Parasitology
Department of Veterinary sciences
Leopoldstr. 5
80802 München